Dimethyl Sulfoxide
Medchemexpress LLC Ruxolitinib10 Mm 1 Ml In Dmso | HY-50856-10MM 1 ML IN DMS
Ruxolitinib10 Mm 1 Ml In Dmso
Apexbio Technology LLC AT9283 896466-04-9 10mM (in 1mL DMSO)
AT9283 (CAS 896466-04-9) is a synthetic small-molecule inhibitor developed through fragment-based drug design It inhibits Aurora kinases A and B key components of the serine/threonine kinase family involved in regulating cell division processes as well as targets including Janus kinases (JAKs) BCR-ABL kinase (including the T315I mutant) and Flt-3 With a potent IC50 around 3 nM against Aurora kinases AT9283 exhibits antiproliferative and pro-apoptotic activity in leukemia myeloproliferative diseases solid tumors and B-cell lymphoma models It is utilized primarily in cancer biology research to investigate its therapeutic potential targeting aberrant kinase activity
Apexbio Technology LLC Methazolamide 554-57-4 10mM (in 1mL DMSO)
Methazolamide (CAS 554-57-4) is a sulfonamide-derived inhibitor of carbonic anhydrase (CA) selectively targeting isoforms CAII and CAIV with IC50 values of 8 1 nM and 80 3 nM respectively By suppressing CA activity methazolamide reduces bicarbonate ion production thus decreasing fluid secretion and intraocular pressure consequently it has clinical use in glaucoma management Recent studies indicate this compound also exhibits insulin-sensitizing properties distinct from other CA inhibitors notably reducing hepatic glucose output suggesting potential applications in diabetes research and metabolic disorders
Apexbio Technology LLC vinblastine 865-21-4 10mM (in 1mL DMSO)
Vinblastine is a naturally-derived alkaloid isolated from Catharanthus roseus It functions as a microtubule inhibitor by binding specifically to tubulin disrupting microtubule polymerization and thereby arresting mitosis at metaphase Due to this mechanism vinblastine is widely investigated for antitumor activities and is commonly employed in biomedical research to study cell division cytoskeletal dynamics and therapeutic interventions in oncology Vinblastine should be stored under sealed dry and cool conditions to maintain molecular integrity and biological activity
Apexbio Technology LLC MC1568 852475-26-4 10mM (in 1mL DMSO)
MC1568 (CAS 852475-26-4) is a histone deacetylase (HDAC) inhibitor derived from the (aryloxopropenyl)pyrrolyl hydroxyamide chemical class It selectively targets class II HDAC enzymes particularly class IIa subtypes (HDAC4 HDAC5 HDAC7 HDAC9) inhibiting maize class II HDAC activity with an IC50 of 22 M MC1568 modulates muscle differentiation pathways by reducing MEF2D expression stabilizing HDAC-HDAC3-MEF2D complexes and preventing MEF2D acetylation in cultured myocytes It also interferes with differentiation signals mediated via RAR and PPAR nuclear receptors serving as a valuable tool in epigenetic and cellular differentiation studies
Medchemexpress LLC Cwi1-2 10 Mm - 1 Ml In Dmso | HY-153274-10MM-1ML DMSO
Cwi1-2 10 Mm - 1 Ml In Dmso
Apexbio Technology LLC Apremilast (CC-10004) 608141-41-9 10mM (in 1mL DMSO)
Apremilast (CC-10004 CAS 608141-41-9) is a small-molecule inhibitor of phosphodiesterase 4 (PDE4) an enzyme involved in cyclic adenosine monophosphate (cAMP) hydrolysis and cytokine signaling pathways By competitively binding PDE4 s catalytic domain apremilast prevents intracellular cAMP degradation (IC50 0 074 M Ki 68 nM) thereby suppressing production of inflammatory mediators such as tumor necrosis factor- interleukin-23 CXCL9 and CXCL10 Due to these anti-inflammatory effects apremilast serves as a significant research tool in autoimmune conditions notably psoriasis and psoriatic arthritis
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 5x10mL
Linear Formula (CH3)2SO, Molecular Weight 78.13, BioPerformance Certified, suitable for hybridoma, Ready-to-use sterile filtered product conveniently packaged in septum screw-capped amber bottles. Meets USP and EP testing requirements.
Apexbio Technology LLC Riociguat 625115-55-1 10mM (in 1mL DMSO)
Riociguat (CAS 625115-55-1) chemically known as BAY 63-2521 is a small-molecule stimulator of soluble guanylate cyclase (sGC) It directly activates sGC independently and also enhances the enzyme s sensitivity to nitric oxide (NO) leading to elevated cyclic guanosine monophosphate (cGMP) levels Elevated cGMP induces smooth muscle relaxation and vasodilation Riociguat has been examined clinically for potential therapeutic roles in chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH)
Apexbio Technology LLC Zafirlukast 107753-78-6 10mM (in 1mL DMSO)
Zafirlukast (CAS 107753-78-6) is an antagonist targeting cysteinyl leukotriene receptors (CysLTR) which mediate inflammatory signaling pathways By competitively inhibiting leukotriene receptor binding it disrupts the leukotriene-driven inflammatory response Zafirlukast demonstrates antagonist potency against leukotriene receptors with an IC50 value of approximately 0 6 M and exhibits moderate inhibitory activity on CYP2C9 enzyme (IC50 of about 7 0 M) In biomedical research Zafirlukast serves as a pharmacological tool for studying leukotriene-mediated inflammation and receptor signaling processes
Apexbio Technology LLC Regorafenib 755037-03-7 10mM (in 1mL DMSO)
Regorafenib (CAS 755037-03-7) is an orally bioavailable inhibitor targeting multiple receptor tyrosine kinases (RTKs) such as VEGFR1/2/3 PDGFR Kit RET Raf-1 B-RAF and B-RAFV600E By impeding kinase phosphorylation (IC50 values ranging from approximately 1 5 46 nM) regorafenib disrupts signaling pathways associated with angiogenesis tumor cell proliferation and metastasis Preclinically regorafenib inhibited VEGFR2 phosphorylation (IC50 3 nM) and reduced VEGF-induced endothelial cell proliferation in vitro In rodent tumor xenograft models it demonstrated dose-dependent tumor growth suppression and antimetastatic potential supporting its utility for oncology research
Apexbio Technology LLC Lopinavir 192725-17-0 10mM (in 1mL DMSO)
Lopinavir is an inhibitor targeting the human immunodeficiency virus (HIV) protease enzyme implicated in viral polyprotein cleavage and maturation Structurally analogous to ritonavir lopinavir binds to HIV protease and suppresses catalytic activity consequently blocking HIV replication It demonstrates potent inhibitory actions against both wild-type and protease-inhibitor-resistant HIV variants Reported inhibition constants (Ki) for lopinavir range between 1 3 and 3 6 pM with antiviral efficacy represented by an EC50 below 0 06 M against protease mutants such as Val82 variants Due to its low susceptibility to inhibition by human serum proteins lopinavir is frequently utilized in antiviral screening assays drug-resistance research and investigations into HIV enzymology and resistance mechanisms
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 1mL
Dimethyl sulfoxide (Standard) is the analytical standard of Dimethyl sulfoxide This product is intended for research and analytical applications Dimethyl sulfoxide (DMSO) is an aprotic solvent that dissolves both polar and nonpolar compounds Dimethyl sulfoxide has anti-freezing and bacteriostatic properties[1][2]
Apexbio Technology LLC LY364947 396129-53-6 10mM (in 1mL DMSO)
LY364947 (CAS 396129-53-6) is a selective inhibitor targeting the kinase domain of transforming growth factor- (TGF- ) type I receptor TGF- signaling regulates crucial biological processes such as cell proliferation differentiation and tissue homeostasis In vitro studies demonstrated that LY364947 inhibits the receptor kinase activity with an IC50 of 51 nM effectively suppressing TGF- -dependent luciferase activity in mink lung epithelial cells (p3TP Lux assay) and growth of NIH 3T3 fibroblasts In vivo LY364947 showed protective effects against NMDA-induced retinal degeneration in rats attenuating retinal ganglion cell loss and capillary degradation Thus LY364947 serves as a valuable pharmacological tool in TGF- -related research and associated pathological conditions